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What is Adderall? Adderall is a top-rated prescription medicine in the United States. Primarily, it is a brand name version for a combination containing amphetamine and Dextroamphetamine. Because of its stimulant properties, Adderall is the most effective medicine for ADHD management. The Food and Drug Administration approved this stimulant medicine in 1960. The administration also has approved Adderall as a generic drug.